New PDF release: 2008-2009 Basic and Clinical Science Course: Section 9:

By Ramana S. Moorthy, MD

A dialogue of the medical method of uveitis results in greatly rewritten chapters on noninfectious (autoimmune) and infectious varieties of uveitis. additionally coated are endophthalmitis, masquerade syndromes, and issues of uveitis. A dialogue on ocular involvement in AIDS has been up to date. The part on immunology describes the human immune reaction in phrases that make it hugely available to readers.

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Extra info for 2008-2009 Basic and Clinical Science Course: Section 9: Intraocular Inflammation and Uveitis (Basic and Clinical Science Course 2008-2009)

Example text

In experimental animals, subretinal transplantation of fetal retinal tissue or various kinds of RPE allografts often show longer survival than the same grafts implanted elsewhere, even without systemic immunomodulation. The afferent phase recognition of alloantigens is likely performed by retinal microglia or recruited blood-derived macrophages from the choriocapillaris. The subretinal cytokine environment remains unknown because transplantation is performed in the setting of retinal diseases, such as retinitis pigmentosa or macular degeneration, in which the blood-retina barrier is altered and retinal cell/RPE injury is present.

24 . Intraocular Inflammation and Uveitis B-Iymphocyte activation One of the major regulatory functions for helper T lymphocytes is B-lymphocyte activation. B lymphocytes are responsible for producing antibodies, which are glycoproteins that bind to a specific antigen. B lymphocytes begin as naive lymphocytes with IgM and IgD on the cell surface; these serve as the B-lymphocyte antigen receptor. Through these surface antibodies, B lymphocytes can detect epitopes on intact antigens and thus do not require antigen processing by APCs.

Snyderman R, cds. Inflammation: Basic Principles and Clinical Correlates. 3rd cd. Philadelphia: Lippincott Williams &Wilkins; 1999. Lymphoid Tissues Primary lymphoid tissues The bone marrow is the site for replenishment and maturation of all leukocyte and lymphoid precursors. Thus, pluripotential stem cells differentiate into various myeloid or lymphoid precursor cells, which then differentiate into monocyte precursors, T- and B-lymphocyte precursors, and so on. B lymphocytes mature within the bone marrow, whereas immature T lymphocytes exit the bone marrow and mature within the thymus.

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