By Daniel M. Albert MD MS, Joan W. Miller MD, Dimitri T. Azar MD, Barbara A. Blodi MD
Contained in the third variation of this esteemed masterwork, countless numbers of the main individual experts from world wide supply cutting-edge most sensible solutions to each query that arises on your perform. They convey in-depth counsel on new diagnostic ways, operative approach, and therapy choice, in addition to cogent causes of each new medical thought and its scientific significance. With its new streamlined, extra hassle-free, full-color structure - in addition to entry to the total contents on-line - this third version makes reference a lot speedier, more uncomplicated, and extra flexible. greater than ever, it is the resource you must successfully and hopefully triumph over any medical problem you'll face.Comprehensive, authoritative, and richly illustrated insurance of each clinical and medical precept in ophthalmology guarantees that you'll regularly have the ability to locate the tips you want to diagnose and deal with your sufferers' ocular difficulties and meet modern criteria of care.Updates contain thoroughly new sections on "Refractive surgical procedure" and "Ethics and Professionalism"... an up to date and improved "Geneitcs" section... an up to date "Retina" part that includes OCT imaging and new drug cures for macular degeneration... and lots of different very important new advancements that impact your sufferer care.A streamlined layout (now 4 volumes rather than six) and a brand new, extra straight forward full-color layout - with many at-a-glance precis tables, algorithms, containers, diagrams, and hundreds of thousands of exceptional colour illustrations - lets you find the help you would like extra quickly than ever. entry to the whole contents of the four-volume set on-line - with speedy seek services and downloadable illustrations - allows you to quick and powerfully reference the cloth from any computer.Your buy entitles you to entry the website till the following variation is released, or till the present version is not any longer provided on the market through Elsevier, whichever happens first. If the subsequent variation is released lower than 12 months after your buy, you may be entitled to on-line entry for 365 days out of your date of buy. Elsevier reserves the fitting to provide an appropriate substitute product (such as a downloadable or CD-ROM-based digital model) may still entry to the website be discontinued.
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Extra info for Albert & Jakobiec’s Principles & Practice of Ophthalmology, Volume 1
Methods to test for a known mutation are simpler and less time consuming than methods used to screen the entire gene. All of the methods used to test for known mutations depend on PCR amplification of a portion of the causative gene, followed by a DNA sequence-dependent assay.  The general principles of these direct methods are illustrated by a more detailed description of the TaqMan assay (Fig. 4). 4 TaqMan Assay. A specific TaqMan oligonucleotide of 20-30 bp is designed to hybridize specifically with the DNA sequence to be tested.
8. Hjalt TA, Semina EV: Current molecular understanding of Axenfeldâ∼ Rieger syndrome. Expert Rev Mol Med 2005; 7:1-17. 9. Sato U, Kitanaka S, Sekine T, et al: Functional characterization of LMX1B mutations associated with nail-patella syndrome. Pediatr Res 2005; 57:783-788. 10. Zhang HZ, Li P, Wang D, et al: FOXC1 gene deletion is associated with eye anomalies in ring chromosome 6. Am J Med Genet A 2004; 124:280-287. 11. Kohlhase J, Chitayat D, Kotzot D, et al: SALL4 mutations in Okihiro syndrome (Duane-radial ray syndrome), acro-renal-ocular syndrome, and related disorders.