By Prof. Dr. Gisela Dallenbach-Hellweg, Prof. Dr. Dr. h.c. Dietmar Schmidt, Dr. Friederike Dallenbach (auth.)
This new version differs from the previous ones in that there was large revision of so much chapters. contemporary advances in examine won via immunohistochemical, molecular organic, and cytogenetic tools are incorporated, so far as they're appropriate for day-by-day diagnostic paintings. The bankruptcy on neoplasms, specifically, has been tremendously elevated based on the recent WHO overseas Histological category of genital tract tumors, overlaying all pertinent differential diagnostic features. The bankruptcy on malignant lymphomas and hematopoetic neoplasms regarding the endometrium is a brand new contribution to this variation (F. D. , Ulm). we've got revised the bankruptcy on gestational illnesses, incorpor- ing fresh advances within the differential analysis of gestational trophoblastic tumors. New discoveries and stories in correlating constitution and serve as in infertility and in h- mone substitute treatment of peri- and postmenopausal sufferers also are integrated. Many new microphotographs were extra to demonstrate the advances in tumor examine and in immunohistochemical detection equipment. we now have up to date the checklist of references together with contemporary suitable courses. To the correspondents and experts who've contributed helpful observations and proposals, bringing thereby to our recognition omissions within the moment variation, we recognize our cordial thank you. We thank Dr. Wolfram Klapper, Director of the L- phom sign up of the collage of Kiel, for case fabric for making the micropho- photograph illustrations of lymphomas. the workers of Springer-Verlag has earned our gratitude for his or her ability in getting ready this new edition.
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Additional resources for Atlas of Endometrial Histopathology
The stroma may contain chronic inflammatory infiltrates comprising mainly lymphocytes and plasma cells (Fig. 3). Morphologic Differential Diagnosis. Foci or nodules of squamous metaplasia can be found in simple, complex or atypical hyperplasia and in well differentiated endometrial G. 1007/978-3-642-01541-0_4, © Springer-Verlag Berlin Heidelberg 2010 45 46 Fig. 1 Ichthyosis uteri. H & E, ×100 Fig. 2 Ichthyosis uteri. 1 Epithelial Metaplasia 47 Fig. 3 Ichthyosis uteri with epithelial dysplasia, overlying atrophic endometritis.
8 Eosinophilic metaplasia with epithelial papillae. 2 Stromal Metaplasia In rare instances the endometrial stromal cells undergo metaplastic changes. Small foci of smooth muscle metaplasia may occasionally be observed (Fig. 9). Cartilagenous, osseous, fatty, or glial metaplasia has rarely been found. Morphologic Differential Diagnosis. Stromal metaplasia must be distinguished from: (a) fetal remnants (the metaplastic cells merge with normal stromal cells at their periphery and do not react as foreign inclusions or growths); (b) mixed mesenchymal tumors by their minimal size and benign histologic appearance.
The hemorrhage is confined to the upper layer of the endometrium and ends sharply at the internal uterine os. In less recent hemorrhages, there may be necrosis of stromal cells and loss of reticulin fibers as well as degeneration of the glandular epithelium within the affected parts and, rarely, scattered aggregates of polymorphonuclear leukocytes. The endometrium is usually atrophic and reactive changes remain restricted; therefore, hemosiderin-laden macrophages are not seen. Morphologic Differential Diagnosis.