By Jacqueline Jumpsen
'This book's target is to supply a targeted evaluation (morphological, biochemical and sensible) of mind improvement and to exemplify the function of lipids within the very important developmental occasions and the innovations which are most likely altered through physiological adjustments in mind lipid composition. person chapters comprise: mind development and vulnerability; mind lipids; Lipids and crucial fatty acids in mind improvement; crucial fatty acid synthesis and shipping to the mind; impression of nutrition on fatty acid composition in mind; Glycolipids and gangliosides; Neurotransmitters; and Relevance, reflections and destiny directions.'
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Extra info for Brain development : relationship to dietary lipid and lipid metabolism
A recent review (Shatz, 1990) suggests that the normal development of orderly sets of connections in the visual system is driven by patterned, spontaneously generated activity even before vision begins. In this respect, neuronal activity generated from within the nervous system or from the environment can affect the development and/or maintenance of connections among cells in the visual system. Although the retina and visual cortex are linked through optic nerves and the lateral geniculate nucleus, the reversibility of retinal abnormalities does not indicate an absence of long-lasting changes in the responsiveness of the visual cortex.
Side-to-side connections are achieved by the horizontal and amacrine cells. Subgroups within each of these major cell classes exhibit important differences in structure and function. During development, the outer segment plasma membrane of rod cells evaginates and produces a stack of disc-shaped lipid-bilayer membranes. The predominant membrane protein within the rod outer segment is rhodopsin. This protein is responsible for trapping light (Knowles, 1982). During visual processing, incoming light strikes the photoreceptors and generates electrical signals, which are sent to bipolar cells and ganglion cells.
The primary product of 18:3n-3 elongation-desaturation was observed to be eicosapentaenoic acid (20:5n-3) with some labeled 22:5n-3 also present. However, no 22:6n-3 was detected. This again suggests a lack of ∆-4 desaturase activity. As well, it was noted that endothelial cells also take up preformed 20:4n-6 and 20:5n-3 when they are available in the extracellular fluid. However, Rosenthal (1987) noted that essentially all cells in culture readily and nonspecifically take up free fatty acids from culture medium and incorporate these into cellular phospholipids and triacylglycerols.