By Robert Shapiro (auth.), Erling Seeberg, Kjell Kleppe (eds.)
The NATO - EMBO complicated examine Institute - Lecture direction on "CHROMOSOME harm and service" was once held at God¢ysund Fjord resort outdoors Bergen, Norway. from Ms\r twenty seventh to June fifth, 1980. This e-book represents the lawsuits of this assembly. as well as the for mal lectures, a couple of brief contributions awarded within the dis cussion periods following the lectures also are integrated. The papers were divided into assorted teams in line with subject, basically within the similar approach as they have been provided through the meet ing. The editors have m. ade' few changes within the manuscript sub mitted and those have been often constrained to typing type and correc tion ot typographical blunders. we want to precise our appreciation to all of the individuals who helped in making this assembly attainable. designated thank you are because of Tomas Lindahl, Alan R. Lehmann and Erik Boye, who served within the advisory application committee. we'd additionally wish to thank our Danish buddies and co-workers and others who supplied precious tips in an emergency scenario. The editors also are thankful for the monetary aid supplied by means of a couple of corporations and institu tions. initially of those have been the NATO medical Affairs department and the ecu Molecular Biology Organization.
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Extra resources for Chromosome Damage and Repair
Mol. • 67:375 (1972). 7. M. Pohl. Polymorphism of a synthetic DNA in solution. Nature. 26:365 (1976). 8. J. Wang. J. Quigley. J. Kolpak. L. Crawford. H. van Boom. G. van der Marel and A. Rich. Molecular structure of a left-handed double helical DNA fragment at atomic resolution. Nature. 282:680 (1979). 9. P. P. Fuchs. Structural modification of DNA after covalent binding of a carcinogen in: "R~paration du DNA. mutag~nese. canc~rog~nese chimique". • CNRS Paris (1977). 10. D. B. Weinstein. Conformational changes in nucleic acids modified by chemical carcinogen.
45045 Orleans Cedex. France SUMMARY Two aspects of chemical modifications of DNA by aminofluorene derivatives are considered. On one hand. dC) from the B-form to the Z-form or a Z-like form. On the other hand. the presence of a deacetylated adduct in liver DNA of rats treated with the carcinogen is demonstrated by the use of specific antibodies. Chemical carcinogens can react with nucleic acids and proteins. Until now. most of the works have been devoted to the reaction with DNA. The covalent binding of the carcinogens to DNA can modify the conformation of DNA and consequently the interactions between the modified DNA and some proteins.
Kleppe, unpublished. 10. D. E. Pettijohn and o. Pfenninger, Supercoils in Prokaryotic DNA restrained in vivo, Proc. Natl. Acad. Sci. USA, 77:1331 (1980) . -- ---- ---- ---- - - - - - - 11. K. M. Ulmer, R. F. Gomez, and A. J. Sinskey, Ionizing radiation damage to the folded chromosome of E. coli K-12: Repair of double-strand breaks in DNA, J. BacterIol. 125 I decay in microorganisms: A prokaryotic mo12. R. E. Krisch, del system of examining the role of unrepaired doublestrand DNA breaks in cell killing, in: "Chromosome Damage and Repair", E.