By Anthony T. Campagnoni
The entire tissues of the attention, together with the lens, the cornea, the ciliary physique, the neuroretina and the retinal pigment epithelium needs to paintings in concord for the conclusion of transparent imaginative and prescient. The phenotypic emergence of every of those tissues calls for intercellular verbal exchange, that's accomplished via direct actual touch in addition to via diffusion and reception of the molecular beacons. This quantity offers an summary of the molecular and mobile biology of eye improvement and encompasses topics like early gene expression within the floor ectoderm and the optic cup, retinal neurogenesis, signaling molecules and axonal counsel. It offers new findings at the effect of the lens at the improvement of the visible procedure and the way gene expression within the optic cup controls differentiation of the lens fiber mobile whereas demonstrated rules concerning the morphogenesis of the ciliary physique are challenged. it is a helpful resource of data for developmental biologists and neurobiologists.
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Additional info for Development Of The Visual System (Developmental Neuroscience)
Bar = 100 m. 322 Dev Neurosci 2004;26:318–327 Reza/Yasuda Fig. 3. Expression pattern of crystallins and cytoskeletal proteins in deformed lens. Cryosections prepared from stage 24 embryos electroporated with dominant-negative Pax6 or pFG-EnR were subjected to immunostaining (a–l) and in situ hybridization using ﬁber-speciﬁc CP95 (m–p) and CP49 (q–t) probes. Both ␦- and ␣-crystallins are observed in the malformed lens (e, k) as found in control lens (b, h). CP95 (p) and CP49 (t) transcripts are not observed in malformed lens, whereas they are detectable in the control lens (n, r).
D. 61 Control (normal) denotes non-experimental animals. Contralateral (left) is the unoccluded left eye of the experimental animals whose right eyes were occluded (Occluded (right)). Day 31 in the occluded-right includes 2 weeks of recovery following 2 weeks of occlusion. d. = Not determined. 330 Dev Neurosci 2004;26:328–335 Bhat/Rayner/Chau/Ariyasu Fig. 2. In situ hybridization of chick posterior retina at day 10 (a, d, g), day 17 (b, e, h) and day 31 posthatching (c, f, i). Panels a, b and c show hybridization of Pax-6 in the control retina of untreated chick eyes at day 10, 17 and 31 respectively.
Refractive error (D), axial length (mm), eye weight (g) and number of Pax-6 molecules ! d. d. d. d. d. d. 61 Control (normal) denotes non-experimental animals. Contralateral (left) is the unoccluded left eye of the experimental animals whose right eyes were occluded (Occluded (right)). Day 31 in the occluded-right includes 2 weeks of recovery following 2 weeks of occlusion. d. = Not determined. 330 Dev Neurosci 2004;26:328–335 Bhat/Rayner/Chau/Ariyasu Fig. 2. In situ hybridization of chick posterior retina at day 10 (a, d, g), day 17 (b, e, h) and day 31 posthatching (c, f, i).